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KMID : 0191120020170040483
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Journal of Korean Medical Science
2002 Volume.17 No. 4 p.483 ~ p.489
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Immunoreactivity of CD99 in Stomach Cancer
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Jung Kyeong-Cheon
Lee Han-Soo
Shin Hyung-Sik
Hahn Jang-Hee
Lee Hae-Wan
Park Weon-Seo
Park Young-Euy
Bae Young-Mee
Hahn Kyu-Hyoung
Koo Hyung-Jin
Shin Hai-Jeong
Park Seong-Hoe
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Abstract
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CD99 is characteristically expressed in Ewing´s sarcoma/primitive neuroectodermal tumor. Recently its immunoreactivity has also been reported in other tumors. However, the significance of CD99 isoforms expressed in these tumors has not been
elucidated.
In this study, we evaluated the expression of CD99 isoforms and its relationship with histopathologic parameters in gastric adenocarcinomas. Paraffin sections of 46 gastric adenocarcinomas were stained with an anti-CD99 monoclonal antibody, YG32.
Twelve
(26.1%) cases of 46 gastric adenocarcinomas showed immunoreactivity to YG32. The CD99 expression was also seen both in non-neoplastic foveolar epithelial cells and infiltrating lymphocytes. In addition, Western blot and RT-PCR analyses revealed
that the
typeⅠis the predominant isoform of CD99 in non-neoplastic and neoplastic gastric tissues. The CD99 expression was usually seen in the intestinal type adenocarcinoma, while rarely in the diffuse type. The CD99 immunoreactivity decreased in
MMP-2-overexpressing adenocarcinomas (p=0.028). Our results suggest that the typeⅠis the major isoform of CD99 expressed in non-neoplastic gastric mucosa and gastric adenocarcinomas and its downregulation in gastric adenocarcinoma may be
associated
with cellular dedifferentiation and/or MMP-2 overexpression.
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KEYWORD
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CD99, Stomach Neoplasms, Adenocarcinoma, Matrix Metalloproteinases,
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